AttributeDetails
Type of DrugPhosphodiesterase type 5 (PDE5) inhibitor
Health Conditions Prescribed ForErectile dysfunction, benign prostatic hyperplasia, pulmonary arterial hypertension
Active IngredientsTadalafil
Brand NamesCialis, Adcirca
Available Strengths2.5mg, 5mg, 10mg, 20mg
Available AsTablets
Possible Side EffectsHeadache, flushing, nasal congestion, indigestion, back pain, dizziness
ManufacturersEli Lilly and Company, various generic manufacturers

What is Tadalafil?

Tadalafil is a prescription medication primarily used to manage erectile dysfunction. It belongs to a class of drugs called PDE5 inhibitors, which work by relaxing blood vessels and enhancing blood flow to specific areas of the body. Unlike other ED medications, Tadalafil has an extended duration of action, remaining effective for up to 36 hours. This unique feature has earned it the nickname “The Weekend Pill.”

What is Tadalafil Used For?
Tadalafil addresses conditions linked to blood flow and vascular function. Its primary uses include:

Erectile Dysfunction (ED): Enhances blood flow to the penis, enabling firmer, longer-lasting erections with up to 36 hours of effectiveness.
Benign Prostatic Hyperplasia (BPH): Relaxes bladder and prostate muscles, reducing urinary issues like frequent urination and incomplete bladder emptying.
Pulmonary Arterial Hypertension (PAH): Relaxes lung blood vessels, easing symptoms and improving exercise capacity.
Dual Benefits: Simultaneously treats ED and BPH, offering convenience for men with both conditions.
 
At 123Meds, we offer Tadalafil for the treatment of Erectile Dysfunction only - if you are interested in using Tadalafil for any other condition, we would advise that you seek further review from your GP to determine whether it is an appropriate treatment option.

How Tadalafil Works
Tadalafil works by inhibiting the PDE5 enzyme, which controls blood flow regulation in the body, especially in the penis. By blocking PDE5, Tadalafil improves blood circulation, enhancing erectile function.

Enhances Blood Flow- Tadalafil relaxes blood vessel walls, improving blood flow, particularly in the pelvic area, which is essential for sexual activity.

Prolonged Effect- Known as the “weekend pill,” Tadalafil’s effects can last up to 36 hours, offering more flexibility and less pressure on timing sexual activity.

Targeted Action- It focuses on the penis while minimising impact on other systems, ensuring effectiveness with fewer side effects.

When is Erectile Dysfunction Confirmed and Medication Needed?

Erectile dysfunction (ED) is confirmed when a man consistently has trouble achieving or maintaining an erection sufficient for sexual intercourse. Occasional difficulties, such as those caused by stress, anxiety, or fatigue, are common and typically not a cause for concern.

However, when the issue persists for several weeks or months, it may indicate a deeper health problem  - If ED has been a persistent problem for you or something that has developed suddenly, we would advise that you seek further review from your GP to exclude the presence of an underlying medical condition that could be a contributing factor.

Can You Buy Tadalafil Over the Counter?

In the UK, Tadalafil is classified as a prescription-only medication, which helps to  ensure that the medication is used safely and appropriately.

Alternative Medications for Erectile Dysfunction

If Tadalafil is not suitable or preferred, there are a number of alternatives that may be suitable. Your 123Meds prescriber will look to recommend you a treatment based upon your medical history, including your previous experiences with the use of ED treatments.

Sildenafil (Viagra):

This is one of the most well-known treatments for erectile dysfunction.
It is effective for most men and typically starts working within 30-60 minutes after ingestion.
Its effects last for about 4-6 hours, making it ideal for short-term use.
Sildenafil is widely available and has a strong track record of safety and efficacy.

Vardenafil (Levitra):

This medication is similar to Sildenafil but is often noted for its quicker onset of action, sometimes working in as little as 15 minutes.
It provides consistent results and is effective for a similar duration of 4-6 hours.
Vardenafil may be particularly beneficial for men with diabetes, as studies suggest it may work better in this population compared to other PDE5 inhibitors.

Avanafil (Spedra):
A newer addition to the PDE5 inhibitor category, Avanafil is designed for rapid action.
It begins working in as little as 15 minutes, offering convenience for spontaneous situations.
Avanafil is associated with fewer side effects, such as headaches or flushing, compared to other options, making it a popular choice for men seeking a milder medication.

Important Considerations
Always consult a healthcare professional to determine the best medication based on your specific needs and health profile.

How to take Tadalafil

  • Daily Use: Take 2.5mg or 5mg daily for continuous effectiveness.
  • On-Demand Use: Take 10mg or 20mg as needed, at least 30 minutes before sexual activity.


Timing

Tadalafil offers flexibility with its long duration of action (up to 36 hours), allowing spontaneity in planning intimate moments.

With or Without Food

You can take Tadalafil with or without meals, but avoid heavy or fatty foods as they may delay its effectiveness.

Avoid Alcohol

Excessive alcohol can reduce the drug’s efficacy and increase side effects like dizziness and headaches.

Missed Dose

If you’re on a daily dose and miss one, take it as soon as you remember. Skip the missed dose if it’s almost time for the next one. Never double up to compensate for a missed dose.

Warnings

Always follow your prescribers  instructions. Avoid using Tadalafil with nitrates or other medications that could cause unsafe blood pressure drops.

Active Ingredients

Tadalafil: The active compound responsible for the therapeutic effects.

Inactive Ingredients

  • Hypromellose, Triacetin, Titanium Dioxide, Iron Oxide: Used for coating and appearance.
  • Magnesium Stearate: Lubricates and stabilizes the tablet.
  • Croscarmellose Sodium: Helps the tablet dissolve quickly.
  • Lactose Monohydrate: A filler to bind the tablet.


Note
: Inactive ingredients may vary between manufacturers. Always check the packaging or prescription for specific details and make your prescriber aware if you have any allergies. If you do have any allergies and are unsure whether our treatments are suitable for you, please contact us before taking any medication that has been prescribed.

While Tadalafil is generally well-tolerated, it may cause some side effects. Understanding these can help users manage expectations and know when to seek medical attention. 

Common Side Effects

  • Headache
  • Flushing
  • Nasal Congestion
  • Indigestion
  • Back Pain
  • Muscle Aches
  • Dizziness
  • Vision Changes

These effects are usually mild and temporary, resolving on their own without intervention.

Rare but Serious Side Effects

  • Priapism: A prolonged erection lasting over four hours, which can cause permanent damage if not treated promptly.
  • Severe Allergic Reactions: Symptoms like swelling of the face or difficulty breathing require immediate medical attention.
  • Sudden Vision or Hearing Loss: Although rare, these symptoms necessitate urgent consultation with a healthcare provider.

If any severe or persistent symptoms occur, discontinue use and seek urgent medical evaluation from your GP, NHS111 or A&E as appropriate. 

  • What conditions can Tadalafil treat?

    Tadalafil is used primarily to treat erectile dysfunction (ED), benign prostatic hyperplasia (BPH), and pulmonary arterial hypertension (PAH). It improves blood flow to the penis, alleviates urinary symptoms caused by an enlarged prostate, and relaxes lung blood vessels to help with PAH. Its versatility makes it a valuable medication for managing multiple conditions.

  • How does Tadalafil work in the body?

    Tadalafil works by inhibiting the enzyme PDE5, which restricts blood flow in certain areas of the body. By relaxing blood vessels, it enhances blood flow, particularly to the penile region, aiding in erections.

  • How long does Tadalafil take to start working?

    Tadalafil typically begins working within 30 minutes of consumption. However, its effectiveness may vary depending on factors like individual metabolism and the presence of food in the stomach. Its effects can last up to 36 hours, offering flexibility in planning intimate activities.

  • Can Tadalafil be taken daily?

    Yes, Tadalafil can be taken daily in lower doses (2.5mg or 5mg), especially for men who require ongoing treatment for ED. Daily dosing helps maintain consistent levels of the medication in the body, enabling spontaneous sexual activity. Always follow the advice provided by your prescriber when using any medication that has been prescribed to you.

  • What should I do if I miss a dose of Tadalafil?

    For daily use, take the missed dose as soon as you remember unless it’s almost time for the next dose. If you’re using Tadalafil on an as-needed basis, skip the missed dose and follow your regular schedule. Do not take extra doses to make up for a missed one, as this can lead to side effects.

  • What are the common side effects of Tadalafil?

    Common side effects include headaches, nasal congestion, flushing, indigestion, back pain, and dizziness. These effects are usually mild and resolve on their own. If you experience severe side effects like prolonged erections or vision changes, seek medical attention immediately.

  • Can Tadalafil be used with alcohol?

    While Tadalafil can be taken with moderate alcohol consumption, excessive drinking can reduce its effectiveness. Alcohol may also increase the likelihood of side effects like dizziness, headache, and low blood pressure. It’s best to limit alcohol when using Tadalafil to ensure optimal results.

  • Is Tadalafil safe for women to use?

    Tadalafil is not approved for use in women and is primarily prescribed for male-specific conditions like ED and BPH.

  • What is the difference between Tadalafil and Sildenafil (Viagra)?

    Tadalafil has a longer duration of action (up to 36 hours) compared to Sildenafil (4–6 hours). This allows more flexibility and spontaneity in intimate activities. However, both medications work similarly by increasing blood flow and the ultimate choice will be based upon a comprehensive consultation between yourself and your prescriber.

  • Can Tadalafil help with premature ejaculation?

    Tadalafil is not specifically approved for treating premature ejaculation, but it may help indirectly by improving erectile function. Some men find that having firmer, longer-lasting erections boosts their confidence and delays ejaculation. Treatments for premature ejaculation should not be typically used alongside ED medication, as the combined action of the medication can lead to significant side effects.

  • Is Tadalafil safe for heart patients?

    Tadalafil can be safe for some patients with heart conditions, but it should not be taken with nitrate medications, as this combination can cause a dangerous drop in blood pressure. Always inform your prescriber about any medical conditions or medicines that you are using, to ensure that the prescribed treatment is safe and appropriate.

  • Can I take Tadalafil with food?

    Yes, Tadalafil can be taken with or without food. However, avoid heavy or fatty meals, as they may delay its absorption and reduce its effectiveness. A balanced meal is generally best when taking the medication.

  • What medications should not be combined with Tadalafil?

    Tadalafil should not be used with nitrates, alpha-blockers, or certain antifungal or antibiotic medications. These combinations can lead to severe drops in blood pressure or other adverse reactions. Always provide your 123Meds prescriber with details of all the medication that you are using to ensure that the treatment prescribed is safe and appropriate.

  • What precautions should I take while using Tadalafil?

    Avoid excessive alcohol and grapefruit products, as they can interfere with Tadalafil’s effectiveness. Always inform your 123Meds prescriber about any pre-existing conditions, such as heart problems or kidney disease. Do not take Tadalafil if you are allergic to it or are already using another ED medication.

  • Can older adults use Tadalafil safely?

    Yes, older adults can use Tadalafil, however dosage adjustments may be needed due the potential of enhanced lowering of blood pressure in older adults. Your 123Meds prescriber will provide you with further guidance as appropriate.

  • What happens if I take too much Tadalafil?

    Taking too much Tadalafil can increase the risk of side effects like headaches, dizziness, prolonged erections, or low blood pressure. In severe cases, it may lead to medical emergencies requiring immediate attention. Always stick to the prescribed dose and if you do experience any side effects, particularly those that are persistent or severe in nature, urgent medical attention should be sought.

  • Can Tadalafil be purchased over the counter?

    In most countries, including the UK, Tadalafil is a prescription-only medication. This ensures proper evaluation of your condition and suitability for the medication. 123Meds is a GPHC registered pharmacy with UK based prescribers, enabling you to receive treatment from a trusted source.

Our 5-Point Safety Guarantee

We focus on trust, privacy, and expert service in online medication ordering.

GPHC and MHRA Regulated Pharmacy icon

GPHC and MHRA Regulated Pharmacy

Regulated by all necessary UK regulatory bodies

UK qualified Pharmacists icon

UK qualified Pharmacists

All consultations reviewed by UK pharmacists

Authentic Medication icon

Authentic Medication

Sourced from approved suppliers only

Customer Care icon

Customer Care

Customer care team available via email or phone

Trusted by Thousands icon

Trusted by Thousands

Thousands of satisfied customers

UK Prescribers &<br>pharmacists icon
UK Prescribers &
pharmacists
100% Discretion on all<br>consultations & orders icon
100% Discretion on all
consultations & orders
Express next day<br>delivery before 3:30PM icon
Express next day
delivery before 3:30PM
Online Prescription<br>Available Now icon
Online Prescription
Available Now