What is Rozex Gel

Rozex Gel is a topical prescription medication formulated to manage rosacea, a chronic skin disorder characterised by persistent facial erythema, telangiectasia, and inflammatory lesions. Metronidazole works by reducing neutrophil‑mediated reactive oxygen species and suppressing bacteria and Demodex mites associated with rosacea. It is applied directly to affected areas and is intended for adult use only under the supervision of a prescriber.

Indications

Rozex Gel is indicated for:

Inflammatory papules and pustules of rosacea
Persistent facial erythema in rosacea

Rozex is not indicated for:

• Acne vulgaris (common juvenile acne)
• Bacterial or fungal infections unrelated to rosacea
• Perioral dermatitis- Can be used off license.

Mechanism of Action

1. Anti‑inflammatory: Metronidazole inhibits reactive oxygen species from neutrophils, reducing inflammation.
2. Antimicrobial: It suppresses Demodex mites and bacteria linked to rosacea flares.
3. Over time, consistent use decreases lesion number, reduces redness, and lessens flare frequency.

When Should You Use Rozex

Persistent or Treatment-Resistant Rosacea Symptoms:

Rozex Gel is commonly prescribed for adults suffering from persistent papules, pustules, and facial erythema (redness) associated with rosacea. It is particularly suitable when non-prescription skincare measures—such as gentle cleansers, fragrance-free moisturisers, and lifestyle adjustments (like avoiding common rosacea triggers such as spicy foods, alcohol, extreme temperatures, and stress)—have failed to provide sufficient control over flare-ups. 

Suppose redness, swelling, and spot-like inflammatory lesions continue to appear despite these efforts. In that case, your healthcare provider may recommend Rozex Gel as a prescription-only option to help manage the condition effectively.

Ideal for Inflammatory Lesions and Facial Redness:

Rozex Gel is specifically designed to treat the inflammatory component of rosacea, targeting both papules and pustules alongside persistent facial redness. It works by reducing inflammation and microbial activity in the skin, helping to control the symptoms associated with this chronic condition. 

However, Rozex Gel is not indicated for use in other dermatological conditions, such as acne vulgaris (common acne), bacterial or fungal skin infections, or perioral dermatitis. A GP or dermatologist must confirm the diagnosis of rosacea before commencing treatment.

Course Duration and Application:

A typical treatment regimen with Rozex Gel involves applying a thin layer of the gel to the affected facial areas once or twice daily, strictly as instructed by your healthcare provider. Before application, the skin should be gently cleansed with a mild soap-free cleanser and thoroughly dried.

Treatment generally continues for 8 to 12 weeks to achieve optimal results, although some individuals with chronic rosacea may require longer treatment durations under ongoing medical supervision. Your prescriber will periodically assess your response to the medication and determine the need for continued or adjusted therapy based on your skin’s condition and tolerability.

Precautions and Usage Guidelines:

Rozex Gel is not appropriate for every patient. It should not be used by individuals who are hypersensitive to metronidazole or any other nitroimidazole derivatives. Caution is necessary in patients with a known history of blood dyscrasias (blood disorders), as the medication could potentially exacerbate such conditions.

The gel must not be applied to broken or severely damaged skin, nor should it come into contact with mucous membranes, such as the eyes, mouth, or nasal passages. Sun exposure and UV light should be avoided during treatment, as they can increase the likelihood of skin irritation or photosensitivity. Additionally, inactive ingredients may vary slightly between different licensed manufacturers, so always refer to the specific product information leaflet provided with your medication if you have sensitivities to certain excipients.

Adherence and Follow-Up:

Strict compliance with your prescriber’s directions is essential when using Rozex Gel. Overuse, missed doses, or premature discontinuation of the gel can reduce its effectiveness and may heighten the risk of unwanted effects such as skin dryness, peeling, or stinging. 

Your doctor or dermatologist will likely schedule follow-up appointments to evaluate your skin’s response, monitor for any adverse reactions, and decide whether treatment should continue, be adjusted, or stopped entirely based on your progress. Consistent use as directed offers the best chance of achieving and maintaining symptom relief.

Precautions and Safety

Allergy alert: Do not use if you have hypersensitivity to metronidazole or nitroimidazole derivatives.
Skin conditions: Avoid applying to open wounds, infected, or atopic skin.
Blood disorders: Cautioned in patients with a history of blood dyscrasias; risk of exacerbation.
Avoid mucosa: Do not apply near eyes, nose, mouth, or on broken skin.
Sun protection: Treatment may increase UV sensitivity—use sunscreen and avoid prolonged sun exposure.

Inactive ingredients may vary between manufacturers; if you have excipient sensitivities, review the patient information leaflet or consult your GP.

Follow‑up with your prescriber is essential to review effectiveness or needed adjustments

UK‑Licensed Alternative Medications

If Rozex is not suitable, these prescription medicines may be considered under UK ­guidelines:

Finacea Gel 15 % (Azelaic Acid): Topical anti‑inflammatory—reduces papules and pustules.
Soolantra Cream 1 % (Ivermectin): Miticidal agent effective against Demodex mites.
Mirvaso Gel 0.33 % (Brimonidine): A Vasoconstrictor that rapidly reduces redness.
Oral Doxycycline MR capsules: Low‑dose antibiotic with anti‑inflammatory properties.
Oral Oxytetracycline tablets: Antibiotic alternative for inflammatory rosacea.

These are also prescription‑only medications in the UK.

How to Use Rozex Gel

1. Wash your face using a mild, non-irritating cleanser.
2. Gently pat dry with a clean towel.
3. Apply a thin layer of Rozex Gel to affected areas.
4. Avoid eyes, nostrils, lips, and broken skin.
5. Wash your hands after application.
6. Use once or twice daily, as per your prescriber’s instructions.
7. Continue for at least 8 weeks; ongoing use to be determined during review visits.

Who Should Not Use Rozex

• People allergic to metronidazole or other nitroimidazoles.
• Pregnant or breastfeeding individuals, unless a prescriber performs a risk–benefit assessment.
• A medical practitioner should clear patients with blood disorders.

Precautions & Safety Tips

• Use sunscreen daily and limit UV exposure.
• Report persistent or severe irritation, swelling, or allergic responses.
• Always include: Inactive ingredients may vary between manufacturers.
• Review any other topical therapies with your prescriber to avoid irritation.

Active Ingredients:

Metronidazole 0.75 % w/w

Inactive Ingredients (may vary):

Carbomer 940
Propylene glycol
Methylparaben
Propylparaben
Disodium EDTA
Purified Water

Always read the patient information leaflet (PIL) in your pack for the complete list of ingredients, and to check for any you might be allergic to.

Common side effects (≥1 in 10):

Skin dryness
Mild stinging or burning
Local redness or irritation

Uncommon (<1 in 1,000) but serious:

Severe erythema, blistering, or peeling
Allergic reaction: rash, itching, swelling, especially of the face, lips, or tongue
Paresthesia – tingling or numbness in the treated area

If you experience any severe symptoms, seek immediate medical help from your GP, NHS111 or A&E to avoid complications.