What is Fluconazole 150 mg? 

Fluconazole 150 mg is an antifungal medicine prescribed for the treatment of various kinds of fungal infections, especially the vaginal thrush caused by Candida yeast. It is a specific type of antifungal called azole that has these properties. They were the means by which the growth of fungi was prohibited. The medicine acts by inhibiting the synthesis of ergosterol, which is a part of cell membranes in fungi. This ergosterol kills and disrupts the fungal cells. Initially, it was used for systemic fungal infections, but today, Fluconazole 150 mg is applied to treat vaginal thrush and oral thrush and other conditions. 

What is Fluconazole 150 mg Used For? 

Vaginal Thrush: Fluconazole is used for the treatment of vaginal thrush. Symptoms include itching, allergy, and abnormal discharge. 
Oral Thrush: It is also used to treat a condition known as oral thrush, also known as candidiasis, which may sometimes involve both the mouth and throat. 
Systemic Fungal Infections: It can be utilized in systemic cases of infections where other body parts are also involved. 

How Fluconazole Works 

Fluconazole is an antifungal medicine that inhibits the growth of Candida yeast. It prevents ergosterol synthesis by inhibiting an enzyme that is critical for the process. 

Since there is no synthesis of ergosterol, it increases the instability of the cell membrane in fungal cells and leads to fungal cell death. 

Mechanism of Action: 

Blocks Ergosterol Synthesis: Fluconazole inhibits lanosterol 14α-demethylase, a critical enzyme in ergosterol synthesis. 
Disrupts Fungal Cell Membrane: It disrupts the fungal cell membrane as it stops the production of ergosterol, after which the cell dies. 
Reduces Fungal Growth: It reduces the overgrowth of Candida and other fungi as it targets fungal cells; it does not harm human cells. 

When is Thrush Confirmed and Medication Needed? 

Thrush is confirmed when a person experiences recurring symptoms due to Candida yeast overgrowth. For instance, in vaginal thrush, a woman confirms it when she experiences recurrent irritation, itching, and abnormal discharge, with or without pain during intercourse. Though a few times, the discomfort does not present an infection; however, when the symptom recurs frequently or persists and interferes with daily life and well-being, then thrush becomes an issue. Thrush can be caused by a number of factors including hormonal changes, immune system functions, and lifestyle habits. 

Causes of Thrush: 

Use of Antibiotics: The body may become unbalanced in the bacterial content when using antibiotics. The yeast then overgrows. 
Weak Immune System: Infections can be facilitated in the body when suffering from conditions such as HIV, cancer treatments, or other immune problems. 
Hormonal Changes: Changes in hormone levels, for example, during pregnancy, menstruation, or menopause, may increase the chance of getting thrush. 
Uncontrolled Diabetes: Yeast will multiply when your blood sugar levels are high. 
Other Contributing Factors: Wearing tight-fitting clothes, poor hygiene, or using fragrant products for a long period of time leads to thrush. 

Symptoms of Thrush:

Itching or burning sensations in the vulva and vagina. 
White curd-like clumps of discharge 
Painful or burning sensation during intercourse or urination 
Redness or swelling of the vulva 

If you address these signs, seek medical help. Doctors usually find out if someone has thrush by examining them and looking at their medical history. Fluconazole 150 mg, which is a good antifungal treatment, is often given to treat the infection. Sometimes, other treatments or changes in lifestyle may be suggested to stop it from coming back. In this case, a discussion with a health provider will determine the ideal form of treatment. 

Can Fluconazole 150 mg Be Purchased Over the Counter? 

The medicine is available in some places, such as in the U.K. In many regions, however, a prescription will be required before purchasing this medicine. It cannot be purchased over the counter to treat vaginal thrush in the U.K. This is because Fluconazole is regarded as a prescription-only medication. In some instances, a pharmacist can administer a reduced dose (such as 50 mg) to treat recurrent vaginal thrush without a prescription following discussion with you. It is, therefore, advisable to discuss your condition with a health professional to ensure Fluconazole is appropriate for your condition. Self-diagnosis and self-treatment can result in complications of the infection or side effects. 

Alternative Medications 

Fluconazole is a very effective medicine in treating fungal infections like vaginal thrush. However, there are also other antifungal medications available that may be prescribed by the doctor based on the individual condition. Some of them include the following: 

Clotrimazole (Canesten): This is a commonly used cream in the treatment of vaginal thrush. It functions through the inhibition of Candida yeast. It comes as creams and pessaries that are preferable for some patients as they are not able to take tablets. 
Itraconazole (Sporanox): Itraconazole is another oral antifungal medicine used for systemic infections or more severe cases of thrush. It works in a similar way to Fluconazole by inhibiting the production of the fungal cell membrane. 
Miconazole (Daktarin): Miconazole, or Daktarin, comes as a cream, gel, or pessary. Miconazole is an antifungal medicine; it is also often used for vaginal thrush. It helps kill the fungus causing the infection. 

How to Take Fluconazole 150 mg? 

Timing: The usual dose for the treatment of vaginal thrush is a single dose of Fluconazole 150 mg. It should be taken orally with a glass of water, and the medication will begin to work and alleviate symptoms within hours. Although the medication is quick-acting, it is very important to take the full course of treatment even if symptoms resolve quickly. 

Dosage: The usual dosage for the treatment of vaginal thrush is 150 mg, taken as a single capsule. With Food: It can be taken with or without food as per individual choice. If it is taken with food, the stomach upset will be avoided to some extent. 

Avoid Alcohol: Alcohol doesn't interfere with Fluconazole directly, but excess alcohol intake increases the chances of liver side effects. The doctor advises that the patient must reduce alcohol consumption during the course to avoid such interference and side effects. 

Missing Dose: If you miss a dose of Fluconazole, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed one and continue with your regular dosing schedule. Do not take two doses at once to make up for a missed dose. 

Active Ingredient: 

The active ingredient in Fluconazole is Fluconazole, which stops the growth of Candida yeast and other fungi. It affects the fungal cell membrane, causing the fungus to die and the infection to go away. 

Inactive Ingredients: 

Inactive ingredients include lactose, magnesium stearate, and microcrystalline cellulose. These ingredients help form the tablet, keep it stable, and assist in how the body absorbs the medication. 

The inactive ingredients may be slightly different between brands and makers. Always check the packaging or ask a healthcare provider if you have questions about any ingredients. 

Fluconazole is well-tolerated in most individuals. However, no medication can avoid side effects, and for this reason, some people who use Fluconazole may be experiencing side effects. Most are minor and tend to go away right away. Serious side effects should get urgent medical care. 

Common Side Effects: 

Headache: Common side effect of Fluconazole. 
Upset Stomach: Patients can experience nausea, stomach upset, or indigestion. 
Dizziness: Light-headedness or dizziness can happen at times. 
Skin Rash: In some cases, red skin or skin that is itchy or swollen can be observed. 
Liver Problems: Fluconazole can reduce the functioning of the liver. Symptoms can include yellowing of the skin or eyes (jaundice). 

Less Common but Serious Side Effects: 

Severe Allergic Reaction: Trouble breathing, swelling in the face, lips, tongue, or throat. 
Severe Skin Reactions: In very rare cases, blistering or peeling of the skin occurs. 
Liver Damage: It can lead to liver disease. If the patient experiences any symptoms of liver damage, such as dark urine, stomach pain, or yellowing of the skin, then they need to seek immediate medical attention. 

If you have severe or continuing side effects such as difficulty breathing, a severe rash, or liver problems, seek medical attention immediately. Do not ignore unusual or concerning symptoms because prompt treatment can prevent complications. 

Before you start taking Fluconazole, discuss any pre-existing medical conditions or medications with your doctor to minimize risks. Heed their advice and do not take more than the prescribed dose for safe and effective treatment.