What is Fexofenadine?

Fexofenadine 120mg / 180mg Tablets represent a state‑of‑the‑art approach to allergy management. As a second‑generation antihistamine, fexofenadine hydrochloride works by selectively blocking the H1 receptors, thereby preventing histamine—a chemical mediator released during allergic reactions—from triggering symptoms such as sneezing, runny nose, nasal congestion, and watery, itchy eyes.

This medication is formulated to provide both swift and long‑lasting relief. Its unique non‑sedating profile ensures that, unlike older antihistamines, it does not impair cognitive function or induce drowsiness. This quality makes it especially suitable for individuals who need to maintain full alertness during work or daily activities. The convenience of once‑daily dosing, coupled with its ability to provide continuous symptom control for 24 hours, positions Fexofenadine as a highly effective option for both seasonal and perennial allergies.

In addition to addressing acute symptoms, regular use of Fexofenadine has been shown to reduce the overall frequency and severity of allergic episodes over time. This dual benefit not only alleviates immediate discomfort but also contributes to better long‑term management of chronic allergic conditions. Its safety and efficacy are well‑established through rigorous clinical trials conducted in the UK, making it a preferred choice among healthcare professionals.

What is Fexofenadine Used For?

Seasonal Allergic Rhinitis (Hay Fever): It is used to ease the symptoms that occur during high pollen seasons, such as sneezing, nasal congestion, and itchy, watery eyes.

Perennial Allergic Rhinitis: For individuals who suffer from year‑round allergies triggered by indoor allergens like dust mites, pet dander, or mould, Fexofenadine provides ongoing relief by keeping inflammatory responses at bay.

Chronic Idiopathic Urticaria (Hives): In patients with chronic hives, Fexofenadine helps reduce the number and severity of wheals, as well as the associated itching, thus improving quality of life.

At 123Meds, Fexofenadine is offered as an essential component of comprehensive allergy management. Its dual strength options allow practitioners to tailor the dosage to the severity of the allergic condition. For those whose over‑the‑counter treatments fall short, consulting with a GP ensures that a personalised treatment plan is implemented.

How Does Fexofenadine Work?

Fexofenadine functions by specifically binding to peripheral H1 receptors. In doing so, it prevents histamine from exerting its usual effects, which include the triggering of sneezing, itching, and increased mucous secretion. The selective receptor blockade helps reduce the inflammatory cascade that typically follows exposure to allergens.

Selective Blockade: Fexofenadine’s high affinity for H1 receptors ensures that it efficiently intercepts histamine before it can cause symptomatic reactions.

Rapid Onset: Patients generally notice improvement within an hour of taking the tablet, as the medication quickly reduces histamine-induced inflammation.

Extended Duration: With a pharmacokinetic profile supporting once‑daily dosing, Fexofenadine maintains therapeutic levels for a full 24 hours, offering continuous symptom relief.

Non‑Sedating Nature: Its minimal ability to cross the blood‑brain barrier ensures that it does not cause sedation, allowing individuals to remain productive and alert throughout the day.

This mechanism of action not only provides immediate relief from acute symptoms but also helps in preventing the recurrence of allergic reactions, making Fexofenadine an indispensable option for long‑term allergy management.

Can Fexofenadine Be Purchased Over the Counter?

In the United Kingdom, Fexofenadine is available both as a prescription and over‑the‑counter medication. However, for those experiencing chronic or severe allergic symptoms, it is recommended to consult with a GP or medical practitioner. Professional guidance ensures that the appropriate strength (120mg or 180mg) is prescribed and that any potential interactions or contraindications are carefully managed.

For many patients with mild seasonal allergies, over‑the‑counter Fexofenadine may be sufficient. However, individuals with more persistent or intense symptoms should seek medical advice to ensure a comprehensive treatment approach that may include additional therapies or lifestyle modifications

Alternative Medications

Should Fexofenadine prove unsuitable or less effective for your needs, there are several alternative antihistamines available in the UK. These include:

Cetirizine: A widely used second‑generation antihistamine that offers effective relief for both seasonal allergies and hives, though it may cause slight drowsiness in some users.

Loratadine: Renowned for its non‑sedating properties, loratadine is a popular choice for managing seasonal allergic rhinitis, albeit it may not be as potent in severe cases.

Desloratadine: The active metabolite of loratadine, desloratadine provides long‑lasting relief with minimal sedative effects, making it suitable for chronic allergy management.

Bilastine: A newer antihistamine option that demonstrates a rapid onset of action and prolonged efficacy, ideal for patients with high‑intensity allergic symptoms.

It is crucial to consult your GP or medical practitioner before switching treatments to ensure that any alternative medication is appropriate for your specific condition and overall health profile.

How to Use Fexofenadine 120mg / 180mg Tablets

For optimal results, adhere strictly to the following guidelines:

Dosage Recommendations:

For Seasonal Allergic Rhinitis (Hay Fever): Take one tablet once daily with a full glass of water, ideally before a meal.

Administration Instructions:

Consistency is Key: Take your tablet at the same time each day to ensure steady therapeutic levels in your bloodstream.

Tablet Ingestion: Swallow the tablet whole with water; do not chew or crush it, as this may compromise its controlled-release properties.

Missed Dose: If you miss a dose, take it as soon as you remember. Do not double the dose; simply continue with your regular dosing schedule.

Storage Guidelines:

Keep in Original Packaging: Store the tablets in their original box at room temperature, away from moisture and direct sunlight.

Child Safety: Ensure that the medication is kept out of reach of children.

Expiry Check: Always check the expiry date before use, and do not use the tablets past this date.

Additional Advice:

Follow Medical Advice: Always follow the instructions provided by your GP or included in the patient information leaflet.

Regular Monitoring: Schedule periodic reviews with your GP to assess the effectiveness of your treatment and make any necessary adjustments.

Medication Routine: Maintaining a consistent daily routine with your medication can significantly enhance its efficacy.

Following these directions ensures that Fexofenadine provides the maximum benefit in controlling your allergic symptoms.

Active Ingredient:

Fexofenadine Hydrochloride: Each tablet contains either 120mg or 180mg of fexofenadine hydrochloride, which is the principal compound responsible for its antihistaminic action.

Inactive Ingredients:

Lactose Monohydrate: Acts as a filler and binder, ensuring the tablet maintains its form.

Microcrystalline Cellulose: Provides structural integrity to the tablet and aids in its disintegration.

Magnesium Stearate: Functions as a lubricant during the manufacturing process.

Croscarmellose Sodium: Serves as a disintegrant to help the tablet dissolve rapidly upon ingestion.

Sodium Starch Glycolate: Enhances the disintegration process, ensuring quick release of the active ingredient.

Always check the patient information leaflet (PIL) in your pack for the full ingredient list — especially if you have skin allergies or sensitivities.

Common Side Effects:

Headache: Some patients may experience mild to moderate headaches, particularly when beginning the treatment.

Dry Mouth: A transient dryness in the mouth may occur, but it typically resolves as your body adjusts.

Nausea: Mild gastrointestinal discomfort or nausea can be experienced by a few individuals.

Dizziness: A small percentage of users might feel lightheaded; however, this effect is generally short‑lived.

Gastrointestinal Upset: Occasionally, mild stomach upset or loose stools may be noted.

Less Common but Serious Side Effects:

Cardiac Palpitations: In rare instances, some patients may notice a rapid or irregular heartbeat.

Severe Allergic Reactions: Although uncommon, if you experience swelling of the face, lips, or throat, it is critical to seek immediate medical attention.

Intense Dizziness or Fainting: Should severe dizziness or fainting occur, discontinue use and contact your GP promptly.

Persistent Gastrointestinal Disturbances: If nausea or stomach upset continues, consult your healthcare provider for further evaluation.

Note: Seek immediate medical help from your GP, NHS 111, or A&E to avoid complications. Regular monitoring by your GP is advised, particularly if you experience any persistent or severe side effects.