What is Epiduo Gel (Epiduo 0.1%/2.5% Gel)? 

Epiduo Gel is a topical medication used to treat acne. It is available in a 45g tube and combines two powerful ingredients: adapalene (a retinoid) and benzoyl peroxide. These ingredients work together to treat acne by unclogging pores and reducing the bacteria that contribute to acne outbreaks. 

Epiduo Gel helps to clear up existing acne and prevent future breakouts. It is specifically used for treating moderate acne vulgaris and is effective in both teenagers and adults. This gel is easy to apply and is typically used once a day, preferably before bed. 

What is Epiduo Gel (Epiduo 0.1%/2.5% Gel) Used For? 

Treating Acne: Epiduo Gel is primarily used to treat moderate acne vulgaris. 
Reducing Breakouts: It helps to clear up pimples, whiteheads, and blackheads. 
Preventing New Acne: By clearing clogged pores and fighting acne-causing bacteria, it helps prevent new breakouts. 
Improving Skin Appearance: Regular use of Epiduo Gel can improve overall skin texture and appearance. 

How Epiduo Gel (Epiduo 0.1-0.3%/2.5% Gel) Work? 

Epiduo Gel contains two key active ingredients: adapalene and benzoyl peroxide. It is sometimes labeled as Epiduo 0.1%/2.5% Gel, reflecting the concentrations of these components. Additionally, a higher-strength version is available, containing 0.3% adapalene. 

Adapalene helps to reduce pore blockages and inflammation, while benzoyl peroxide targets acne-causing bacteria. It also aids in exfoliating dead skin cells, preventing clogged pores, and reducing the formation of new breakouts. 

When to Consider Epiduo Gel (Epiduo 0.1%-0.3%/2.5% Gel) for Acne? 

Who Should Take Epiduo Gel (Epiduo 0.1%/2.5% Gel)? 

Epiduo Gel is intended for people who suffer from moderate acne. It can be used by both teenagers and adults. If you have acne that is not responding to other treatments or if you have frequent breakouts, Epiduo Gel may be a suitable option. It is also a good option for people looking for a topical solution to help control acne and improve their skin’s appearance over time. 

Who Should Not Take Epiduo Gel (Epiduo 0.1%/2.5% Gel)? 

Sensitive Skin: People with very sensitive skin may experience irritation or dryness from Epiduo Gel. 
Pregnancy: Pregnant women should consult a doctor before using Epiduo Gel due to potential risks to the baby. 
Severe Acne: If your acne is severe or cystic, you may need a more aggressive treatment plan. Epiduo Gel is better suited for moderate acne. 
Allergy to Ingredients: Anyone allergic to adapalene or benzoyl peroxide should avoid using Epiduo Gel. 
Important Considerations: Before starting treatment with Epiduo Gel, it’s important to speak to a healthcare provider. They will help you determine if it’s the right treatment for your skin type and condition.  

If you experience severe irritation, redness, or other side effects, discontinue use and consult your doctor. 

Can Epiduo Gel (Epiduo 0.1%/2.5% Gel) be Purchased Over the Counter? 

Epiduo Gel is not available over the counter. It is a prescription medication that requires a healthcare provider’s approval. This is because Epiduo Gel contains active ingredients that can cause irritation or other side effects if not used properly. You will need to consult with a doctor who will determine if Epiduo Gel is appropriate for your acne treatment. Once prescribed, you can buy it at most pharmacies or online, where prescription medications are sold. 

Alternative Medications 

There are various acne treatments available at 123meds and other sources. Through our online acne clinic, our doctors can prescribe the following treatments: 

Differin Gel (Adapalene) 
Duac Gel (Topical antibiotic & benzoyl peroxide) 
Lymecycline (Oral antibiotic) 
Zineryt (Topical antibiotic) 
Acnecide (Benzoyl peroxide) 
If you haven’t yet tried over-the-counter treatments, there are several options to consider. Popular skincare brands like Clearasil, Witch, Freederm, and Salcura offer acne washes, spot treatments, and gels designed to target breakouts, blackheads, and oily skin. 
In addition to pharmacy treatments, other acne management options include: 
Herbal remedies 
High-dose vitamin treatments 
Homeopathic treatments 
Isotretinoin (Accutane) – A specialist prescription medication available only through a face-to-face consultation.
 
Using Epiduo Gel with Other Medications 

When using Epiduo, avoid other topical acne treatments that contain similar active ingredients. It is also best to steer clear of drying, irritating, or exfoliating skincare products while using Epiduo to prevent excessive skin irritation. 

Pregnancy and Breastfeeding 

Epiduo Gel should not be used if you are pregnant or planning to become pregnant. If you become pregnant during treatment, discontinue use immediately and consult your doctor. 

Epiduo is considered safe to use while breastfeeding, but it should not be applied to the chest area to prevent accidental ingestion by the baby.

How to use Epiduo Gel/cream (Epiduo 0.1%/2.5% Gel)? 

Epiduo is typically applied once daily, preferably at night before bed. Use a thin, even layer on the affected areas after cleansing your face and gently patting it dry. Ensuring your skin is clean and dry before application helps maximize its effectiveness. 

After applying Epiduo, wash your hands thoroughly to prevent accidental contact with sensitive areas and to avoid bleaching fabrics or hair due to the benzoyl peroxide content. 

How to Use Epiduo 

Apply a thin, even layer to acne-affected skin, avoiding the eyes, nostrils, and lips. 
Use once daily, ideally at bedtime. 
Always wash your hands before and after application. 

Epiduo Gel should be applied once daily in the evening. Here’s a step-by-step guide: 

Cleanse Your Skin: Start by washing your face with a gentle cleanser and pat it dry. 
Apply a Thin Layer: Squeeze a small amount of gel onto your fingertip (usually about a pea-sized amount). 
Apply to Affected Areas: Gently apply the gel to the areas affected by acne. Be sure to avoid the eyes, lips, and mucous membranes. 
Wait for It to Absorb: Allow the gel to dry completely before applying any other products. 
Be Consistent: Use Epiduo Gel every night for the best results, even if you don’t see immediate improvements. 

Active Ingredients: 

Adapalene 0.1%  
Benzoyl Peroxide 2.5% 

Inactive Ingredients:  

Water  
Glycerine  
Carbomer  
Sodium hydroxide 

Always check the patient information leaflet (PIL) in your pack for the full ingredient list — especially if you have allergies or sensitivities.

Like any medication, Epiduo may cause side effects, though most people tolerate it well with little to no discomfort. Some individuals may experience mild skin dryness, which can often be managed by using a non-comedogenic moisturizer. 

However, certain side effects are more common. These include skin irritation, a burning sensation in the treated area, and eczema. 

Epiduo can also make your skin more sensitive to sunlight. To reduce the risk of irritation, limit sun exposure and avoid UV lamps while using this treatment. 

For a full list of potential side effects, refer to the patient information leaflet. 

Common Side Effects:  

Redness  
Dryness 
Irritation  
Peeling  
Burning sensation  
Stinging  
Skin discoloration  
Allergic reactions 

Less Common Side Effects: 

Sensitivity to sunlight (sunburns may occur more easily). 
Increased irritation during the first few weeks of use. 

When to Seek Medical Help: 

Severe allergic reactions (swelling, rash, or difficulty breathing). 
Severe dryness or peeling that causes discomfort. 
If side effects persist beyond the first few weeks of use, consult your doctor.