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- Mebendazole Tablets (Generic Ovex)
| Category | Details |
| Type of Medicine | Broad-spectrum anti-helminthic |
| Indications | Threadworm (enterobiasis), roundworm, whipworm, hookworm infestations |
| Active Ingredient | Mebendazole 100 mg per tablet |
| Brand Names | Vermox, Ovex, Mebenda |
| Available Strengths | 100 mg tablets |
| Formulations | Chewable or standard tablets |
| Possible Side Effects | Abdominal pain, diarrhea, flatulence, nausea |
| Contraindications | Hypersensitivity to mebendazole; severe liver disease; pregnancy—first trimester only with caution |
| Manufacturers | GlaxoSmithKline, Janssen, Conway Laboratories, generic suppliers |
What is Vermox?
Vermox is the trade name for mebendazole, a benzimidazole compound that exerts its anti-parasitic action by blocking microtubule formation in helminths. This disruption prevents the parasites from absorbing glucose, leading to energy depletion, immobilization, and eventual death. Mebendazole remains within the gastrointestinal tract, concentrating the effect on luminal worms with minimal systemic absorption (<10%), thereby limiting potential systemic toxicity. The drug’s broad spectrum covers the most common soil-transmitted helminths (STH) and pinworms, making it a versatile treatment in both adults and paediatric populations.
Licensed in the UK for patients aged 2 years and above, Vermox is available as 100 mg tablets, either chewable for younger children or standard for older children and adults. Over-the-counter access is permitted for threadworm (enterobiasis), whereas treatment of other infestations requires a prescription and possibly a repeat dose after 2–3 weeks to target newly hatched larvae, depending on the parasite lifecycle.
What is Vermox Used For?
Primary Indications:
Threadworm (Enterobius vermicularis): Single 100 mg dose; repeat after 2 weeks if reinfection suspected.
Roundworm (Ascaris lumbricoides): 100 mg twice daily for 3 days or 200 mg once daily for 3 days (prescription).
Whipworm (Trichuris trichiura): 100 mg twice daily for 3 days (prescription).
Hookworm (Ancylostoma duodenale & Necator americanus): 100 mg twice daily for 3 days (prescription).
Adjunct Uses:
Mixed Infestations: Combined regimens based on local resistance patterns and parasitology guidance.
Mass Deworming Campaigns: Used in community health programmes for STH control.
At 123Meds, we streamline access for threadworm treatment OTC, while ensuring prescription-only protocols for more serious conditions require GP oversight and possible follow-up dosing to clear reinfections.
How Does Vermox Work?
Mebendazole’s mechanism targets helminth cytoskeletal integrity:
β-Tubulin Binding: Mebendazole selectively binds parasite β-tubulin subunits, inhibiting microtubule polymerization.
Glucose Uptake Blockade: Disruption of microtubules impairs glucose transport in worms.
Energy Depletion: With no glucose absorption, worms exhaust their glycogen stores.
Paralysis & Death: Helminths become immobile, detach from the intestinal mucosa, and are expelled in feces.
Minimal absorption into the bloodstream ensures the drug’s action is highly localized within the gut lumen, reducing potential systemic side effects.
When is Treatment Needed?
Threadworm: Indicated when perianal itching, especially at night, is confirmed by visualizing eggs on perianal swabs or tape tests, or by seeing adult worms. OTC treatment is acceptable upon symptomatic presentation, with emphasis on household treatment.
Soil-Transmitted Helminths: Roundworm, whipworm, and hookworm typically present with nutritional compromise, abdominal discomfort, or eosinophilia. Diagnosis requires stool microscopy and prescription of Vermox under GP care.
Mass Treatment Consideration: School-aged children in endemic areas often receive annual or biannual dosing for STH control, guided by public health protocols and local prevalence data.
Can Vermox Be Purchased Over the Counter?
Yes. Vermox 100 mg chewable tablets are available OTC in the UK solely for threadworm treatment (enterobiasis). For other helminth infections—roundworm, whipworm, hookworm—a prescription is required, as dosing regimens extend beyond the single-dose approach and may necessitate repeat courses or combination therapy.
Pharmacists can supply OTC Vermox after confirming threadworm symptoms and advising on:
Single 100 mg dose now; repeat after 2 weeks if symptoms recur.
Household hygiene measures: washing bedding, clothes, and bathing in the morning to remove eggs.
Potential side effects and when to seek GP review.
Alternative Medications
When Vermox is contraindicated or not tolerated, UK-prescribers may consider:
Albendazole (Zentel): 400 mg single dose for threadworm; 400 mg once daily for 3 days for other STH.
Pyrantel Embonate (Combantrin): 10 mg/kg single dose for threadworm and roundworm; OTC in some formulations.
Ivermectin (Stromectol): 200 μg/kg single dose; used off-label for some STH and in mass drug administration.
Choice depends on parasite species, age, pregnancy status, and local resistance patterns. Always consult your GP before using alternatives.
As threadworms are easily passed from person to person, it is important to treat the whole household at the same time. Good hygiene practices such as handwashing, daily bathing, and washing bedding and clothes can help prevent reinfection
Threadworm (OTC)
Age ≥ 2 years: One 100 mg chewable tablet, crushed or chewed.
Repeat: Single dose repeated after 2 weeks if reinfection suspected.
Administration: Chewable tablet with water, with or after food to minimize GI upset.
Household Measures
Treat all household members simultaneously, even if asymptomatic.
Wash bedding, nightwear, and towels in hot water; vacuum floors and mattresses.
Active:
Mebendazole 100 mg
Inactive:
Lactose Monohydrate
Maize Starch
Microcrystalline Cellulose
Magnesium Stearate
Povidone
Flavoring agents (for chewable tablets)
Always check the patient information leaflet (PIL) in your pack for the full ingredient list — especially if you have allergies or sensitivities.
Common (≥ 1%):
Abdominal pain
Diarrhoea
Flatulence
Headache
Uncommon (< 1%):
Nausea & vomiting
Dizziness
Rash & urticaria
Rare/Serious:
Hepatotoxicity (elevated liver enzymes)
Bone marrow suppression (neutropenia)
Severe hypersensitivity
Note: Seek immediate help if you develop jaundice, severe rash, or signs of infection.
How quickly does Vermox work against threadworms?
Once you take the single 100 mg dose of Vermox, mebendazole begins paralyzing adult threadworms by disrupting their glucose uptake. Within 24–48 hours, most patients notice reduced perianal itching and may even see dead worms in the stool. The worms detach from the intestinal lining and are expelled naturally. Because eggs can hatch later, a repeat dose after two weeks is recommended to eradicate any newly emerged larvae. Combining the medication with strict hygiene measures, such as daily morning baths and hot bedding washes, maximizes efficacy and prevents reinfestation.
Can I take Vermox during pregnancy and breastfeeding?
Vermox has minimal systemic absorption, and animal studies have not shown clear teratogenic effects. However, first-trimester use is generally avoided unless the potential benefit outweighs theoretical risks. During breastfeeding, mebendazole levels in breast milk are very low, but it’s prudent to discuss with your GP or prescriber to assess any possible impact on the nursing infant. If treatment is essential, timing the dose immediately after a feed and discarding breast milk for 24 hours can further reduce exposure.
Is Vermox safe for young children?
Yes. Vermox is licensed for children aged 2 years and older. The chewable tablet formulation allows precise dosing without tablet splitting. For children between 2 and 5 years, a single 100 mg dose is standard for threadworm, with retesting or repeat dosing as needed. In children under 2 years old, safety data are limited, so always consult a GP for specialist guidance, who may recommend alternative therapies or weight-adjusted dosing to ensure both efficacy and safety.
Why do I need to treat the whole family at once?
Threadworm eggs are microscopic and cling to clothing, bedding, and hard surfaces, leading to rapid household spread. Even asymptomatic carriers can maintain the cycle by passing eggs around. Treating every household member simultaneously with Vermox stops eggs from maturing into adult worms and prevents reinfection. Alongside treatment, thorough hygiene, hot washes of linens, vacuuming carpets, and daily morning showers ensure that stray eggs are removed from the environment, breaking the lifecycle effectively.
What should I do if I miss the repeat dose after two weeks?
If you forget your second 100 mg dose for threadworms, take it as soon as you remember—provided it’s within two to three weeks of the first dose. This interval targets larvae hatched from eggs left behind initially. If more than three weeks have elapsed, consult your GP: they may advise re-treating immediately and then again two weeks later, or performing a stool test to confirm if the infestation persists. This tailored approach ensures all parasite stages are eliminated.
Can I buy Vermox over the counter?
Yes, Vermox 100 mg chewable tablets are available OTC in UK pharmacies for threadworm (enterobiasis). When buying OTC, pharmacists will confirm symptoms and advise on one 100 mg dose now, plus a repeat dose in two weeks. For roundworm, whipworm, or hookworm infections, a prescription is required because treatment regimens extend beyond a single dose and may involve three-day courses. Always follow the pharmacist's or GP’s guidance to ensure appropriate use.
How does Vermox differ from albendazole?
Both Vermox (mebendazole) and albendazole are benzimidazole anti-helminthics, but they vary in absorption and spectrum. Vermox remains largely within the gut, ideal for luminal worms like threadworm and whipworm, whereas albendazole is more systemically absorbed and can treat tissue-invasive parasites (e.g., hydatid disease). Vermox dosing for threadworm is a single 100 mg dose, while albendazole requires single or multi-day dosing at 400 mg. Albendazole’s broader systemic action comes with a slightly higher risk of systemic side effects, so your GP will choose based on the parasite type and patient profile.
Do I need any tests before starting Vermox?
For threadworm, no lab tests are required; OTC treatment is symptom-based. If you suspect other soil-transmitted helminths (roundworm, whipworm, hookworm), your GP may order a stool microscopy sample to identify the specific parasite species. Confirmatory testing helps tailor the dosing regimen, such as three-day courses for STH, and may include liver function tests if repeated dosing is anticipated, especially in patients with existing hepatic concerns.
Are there any common interactions with Vermox?
Mebendazole’s poor systemic absorption (<10%) limits its drug–drug interactions. However, co-administration with cimetidine can slightly raise mebendazole levels by reducing its hepatic metabolism, potentially increasing GI side effects. Rarely, concurrent use with other benzimidazoles or antiparasitics may alter efficacy. Always inform your GP about all prescription, over-the-counter, and herbal supplements to ensure there are no unexpected interactions and to maintain treatment safety.
What side effects should prompt me to seek medical attention?
While Vermox is well tolerated, stop treatment and seek urgent GP review if you experience severe or persistent symptoms:
- Severe abdominal pain or cramping that doesn’t improve with food
- Persistent diarrhea lasting more than 48 hours post-dose
- Jaundice (yellowing of skin or eyes), dark urine, or signs of liver strain
High fever, sore throat, or unusual bruising could indicate bone marrow suppression. These rare events, such as hepatotoxicity or neutropenia, require prompt assessment and possible laboratory tests.
Can I drink alcohol when taking Vermox?
Alcohol does not directly interact with mebendazole, but it can worsen gastrointestinal upset such as nausea or abdominal discomfort. To enhance tolerability, limit or avoid alcohol consumption during treatment. Staying well-hydrated with water or rehydration solutions is more beneficial to systemically flush parasites and reduce potential GI irritation.
How should I store Vermox tablets?
Keep Vermox tablets in their original blister pack or container at 20–25 °C, away from moisture and direct sunlight. Ensure packaging is tightly sealed to maintain potency. Store out of reach of children to prevent accidental ingestion, and always check the expiry date before use. Discard any unused tablets safely once they are out of date.
Will household cleaning alone prevent reinfection?
Cleaning is vital but not sufficient without medication. Remove eggs mechanically by washing bedding, nightclothes, and towels in hot water (≥60 °C) weekly and tumble-dry on a hot setting. Vacuum carpets, upholstery, and mattresses, then wipe surfaces with a damp cloth to capture stray eggs. Personal hygiene—daily morning showers, short fingernails, and discouraging nail-biting—complements Vermox treatment to break the reinfection cycle effectively.
Can Vermox treat other parasites like tapeworms?
No. Vermox (mebendazole) is effective against intestinal nematodes (threadworm, roundworm, whipworm, hookworm) but not tapeworms (cestodes). Tapeworm infections require praziquantel-based therapy. If you notice white segments in your stool or suspect tapeworm infestation, consult your GP for the correct diagnostic tests and treatment regimen.
How does Vermox dosing differ by parasite type?
For threadworm, a single 100 mg chewable dose is generally curative, with a repeat dose after two weeks if reinfection occurs. For roundworm, whipworm, or hookworm, the prescription regimen is 100 mg twice daily for three days, ensuring that both adult parasites and emerging larvae are targeted. Your GP will determine the precise regimen based on species identification, patient age, and any coexisting conditions.
What precautions should I take if I have liver disease?
Although mebendazole’s absorption is low, it undergoes hepatic metabolism via CYP enzymes. In patients with significant liver impairment, your GP may consider dose adjustments, alternative agents, or more intensive monitoring. Periodic liver function tests (LFTs) may be advised if repeat or extended courses are necessary. Report any signs of liver trouble—such as persistent nausea, abdominal pain, or jaundice- immediately to your healthcare provider to ensure safe continuation or adjustment of therapy.
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