What is Lansoprazole? 

Lansoprazole is an acid reducer (a proton pump inhibitor) that lowers stomach acid by blocking the H⁺/K⁺ ATPase in the stomach’s acid-making cells. It is used to treat GERD, acid reflux, and stomach ulcers, easing heartburn and helping the oesophageal and stomach lining heal. It is available in 15mg and 30mg capsules and is usually taken once a day before meals. 

Although it is generally well tolerated, it may cause side effects such as headache, nausea, or diarrhoea. Seek immediate help from your GP, NHS111 or A&E to avoid complications. Lansoprazole is widely trusted for its steady, proven, and reliable health benefits.

What is Lansoprazole Used For? 

Gastroesophageal Reflux Disease (GERD): Reduces stomach acid to ease heartburn and acid reflux symptoms.
Peptic Ulcer Disease: Helps heal stomach and duodenal ulcers by lowering acid production.
Erosive Oesophagitis: Aids in mending irritation in the oesophagus from long-term acid exposure.

At 123Meds, we supply Lansoprazole for treating GERD, acid reflux, and peptic ulcers only – if you want to use Lansoprazole for any other condition, please speak to your GP to check if it is the right treatment option for long-term care.

How Lansoprazole Works 

Lansoprazole works by blocking the H⁺/K⁺ ATPase enzyme in the stomach's acid-making cells, which leads to a big drop in stomach acid production.

Mechanism of Action: 

Inhibition of Proton Pump: Lansoprazole permanently blocks the H⁺/K⁺ ATPase enzyme in stomach acid cells, reducing acid release.
Reduction of Stomach Acid: Lower acid levels ease acid reflux symptoms and help make the right conditions for healing.
Improved Lining Protection: With less acid, the stomach and oesophageal lining can heal much better, helping recovery.

When is Gastroesophageal Reflux Disease (GERD) Confirmed, and Medication Needed?

Gastroesophageal reflux disease (GERD) is diagnosed when frequent, long-term symptoms of acid reflux and heartburn continue despite lifestyle changes and dietary adjustments, often with the return of food, chest pain, or difficulty swallowing. 

A diagnosis is usually based on medical history, an endoscopy, and pH testing, especially when problems such as oesophagitis or Barrett’s oesophagus are suspected. Medication becomes necessary when these ongoing symptoms interfere with daily life or cause complications. In such cases, a proton pump inhibitor like Lansoprazole is given to lower stomach acid, ease symptoms, and help heal the oesophageal lining.

Physical causes of GERD: 

A weak lower oesophageal sphincter does not form a strong barrier, letting stomach acid flow back into the oesophagus.
A hiatal hernia, where part of the stomach pushes through the diaphragm, upsets the normal alignment and encourages acid backflow.
Slow emptying of the stomach raises pressure, making it easier for acid to flow back into the oesophagus.

Psychological causes of GERD: 

Long-term stress and anxiety can raise stomach acid and lead to muscle tension, making GERD symptoms worse.
Depression and long-lasting emotional distress can change how your gut moves and how you feel pain, further worsening acid reflux.

Symptoms of GERD: 

Continuous heartburn and a burning sensation in the chest.
Acid backflow with a sour or bitter taste in the mouth.
Difficulty swallowing with a long-lasting cough or throat irritation.
If acid reflux and heartburn continue for several weeks, it is crucial to seek medical help.

Your general practitioner will review your history and symptoms to confirm a proper diagnosis. Depending on the underlying causes, treatment options may include prescribed medication like Lansoprazole to lower stomach acid and support long-term healing. Based on individual needs, other treatments may also be recommended. It is important to consult a medical practitioner to decide on the right treatment plan.

Can Lansoprazole Be Purchased Over the Counter? 

In the United Kingdom, Lansoprazole is usually available only with a prescription from a healthcare professional. While many over-the-counter medicines can ease occasional heartburn and indigestion, Lansoprazole is mainly used for patients with diagnosed acid-related conditions such as GERD or peptic ulcers. 

Its use requires a proper medical evaluation to ensure safety and correct dosing. Although some lower-dose proton pump inhibitors might be available without a prescription in other regions, in the UK, Lansoprazole is mostly a prescription-only medicine to ensure effective and safe treatment.

Alternative Medications 

While Lansoprazole is a proven choice for treating acid-related conditions, there are several other medicines that offer similar benefits. Each option has its own special features and may be chosen based on the patient's needs and response to treatment.

Omeprazole: Omeprazole is a widely used proton pump inhibitor that effectively lowers stomach acid production. Like Lansoprazole, it is prescribed for GERD, ulcers, and related conditions. Its safety record and availability in both generic and branded forms make it a popular alternative. It offers similar results in relieving symptoms and healing the stomach lining.
Esomeprazole: Esomeprazole is a newer S-isomer of omeprazole designed to offer improved acid suppression. It is commonly used in patients who require consistent and effective treatment for GERD and erosive oesophagitis. With a similar safety record, esomeprazole provides reliable symptom relief and promotes healing in acid-related conditions, ensuring effective, long-term management.
Pantoprazole: Pantoprazole is another effective proton pump inhibitor used to lower stomach acid production. It is particularly beneficial for patients with GERD and erosive oesophagitis. Known for its favourable side effect record, pantoprazole offers a reliable alternative with consistent acid control and improved healing of the stomach lining, ensuring optimal recovery.

If you are unsure about the best treatment for you, please speak with your 123Meds prescriber for personalised advice.

How to Take Lansoprazole? 

Timing: Take Lansoprazole in the morning, at least 30 minutes before breakfast.

Dosage: The recommended dose of Lansoprazole depends on how serious your condition is and your prescriber's instructions. Typically, patients with mild symptoms might be given a 15mg capsule daily, while those with more serious conditions such as GERD or peptic ulcers might need a 30mg dose once a day. Your treatment period may last from 4 to 8 weeks, after which your physician will check your progress. Do not change your dose or treatment duration without consulting your healthcare provider. Always follow your prescriber's specific dosing instructions to ensure the best results for steady and effective acid control.

With Food: Lansoprazole works best when taken on an empty stomach, ideally at least 30 minutes before a meal. This timing lets the medication be fully absorbed and helps control stomach acid effectively. Taking it with food may lower its effectiveness, so follow your prescriber's instructions.

Avoid: Avoid taking Lansoprazole with foods or drinks that can reduce absorption, such as high-fat meals and dairy products. Do not use antacids within an hour of your dose, as they may make the medication less effective. Also, avoid alcohol during treatment, as it can interfere with how well the medicine works.

If you miss a dose of Lansoprazole, take it as soon as you remember unless it's nearly time for your next dose. Do not double your dose; instead, consult your medical practitioner for guidance.

Lansoprazole contains both active and inactive ingredients that work together to provide effective acid control.

Active Ingredients:

The active ingredient in Lansoprazole is Lansoprazole, a proton pump inhibitor that blocks the H⁺/K⁺ ATPase enzyme in the stomach’s acid-making cells. This action greatly lowers stomach acid production, helping to ease symptoms of GERD, acid reflux, and peptic ulcers.

Inactive Ingredients:

Inactive ingredients such as microcrystalline cellulose, magnesium stearate, and croscarmellose sodium help form the capsule, keeping it stable and ensuring it dissolves properly for best absorption. These components may vary between manufacturers, so please check the packaging or contact us for further assistance.

Note - Inactive ingredients may vary from manufacturer to manufacturer.

Lansoprazole is usually safe for most patients, but like all medicines, it can cause side effects. Most side effects are minor and short-lived; however, some more serious side effects need prompt medical attention.

Common Side Effects:

Headache: A common side effect in patients taking Lansoprazole.
Diarrhoea: Loose stools and an upset stomach can occur.
Nausea: Some people may experience mild nausea.
Abdominal Pain: Stomach discomfort or cramps are possible.
Constipation: Difficulty with bowel movements may be experienced.
Dizziness: Feeling lightheaded may occur.
Flatulence: Increased gas is a common symptom.
Skin Rash: Red, itchy skin may develop in rare cases.

Less Common but Serious Side Effects:

Low Magnesium: Extended use may lead to low magnesium levels, requiring a medical check-up.
Bone Fractures: Long-term treatment can increase the risk of fractures, particularly in older patients.
Serious Allergic Reactions: Symptoms such as swelling and difficulty breathing need immediate medical help.

If you experience strong or long-lasting side effects such as severe stomach pain, serious allergic reactions (including swelling of the face, lips, tongue, or throat), or ongoing tummy troubles, seek immediate medical help by visiting your A&E (Accident and Emergency) department. Don’t ignore unusual or worrying symptoms, as quick care can stop problems.

Before starting Lansoprazole, please make sure you have told your prescriber about all your current health conditions so they can decide on the best treatment and dose for your condition.